Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

@article{Mills2016SuccinateDS,
  title={Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages},
  author={Evanna L. Mills and Beth Kelly and Angela Logan and Ana S. H. Costa and Mukund Varma and Clare E Bryant and Panagiotis Tourlomousis and Jan D{\"a}britz and Eyal Gottlieb and Isabel J Latorre and Sin{\'e}ad C. Corr and Gavin J McManus and Dylan Gerard Ryan and Howard T. Jacobs and Marten Szibor and Ramnik J. Xavier and Thomas Braun and Christian Frezza and Michael P Murphy and Luke A. J. O’Neill},
  journal={Cell},
  year={2016},
  volume={167},
  pages={457-470.e13}
}
Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate that upon lipopolysaccharide (LPS) stimulation, macrophages shift from producing ATP by oxidative phosphorylation to glycolysis while also increasing succinate levels. We show that increased mitochondrial oxidation of succinate via succinate dehydrogenase (SDH) and an elevation of mitochondrial membrane potential combine… CONTINUE READING
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