Successive waves of apoptosis in the rat prostate after repeated withdrawal of testosterone stimulation.

Abstract

In rats with castration-induced ventral prostatic atrophy, testosterone treatment resulted in reconstitution of the normal weight and histological structure of the gland within 10 d. Subsequent withdrawal of the hormone was followed by rapid involution, which was effected by a combination of extensive loss of epithelial cells by apoptosis and decrease in… (More)

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