Successive generation of antigen-presenting, dendritic cell lines from murine epidermis.

@article{Xu1995SuccessiveGO,
  title={Successive generation of antigen-presenting, dendritic cell lines from murine epidermis.},
  author={Shuichan Xu and Kiyoshi Ariizumi and G C{\'a}ceres-Dittmar and Dale Edelbaum and Katsunori Hashimoto and Paul R. Bergstresser and Akira Takashima},
  journal={Journal of immunology},
  year={1995},
  volume={154 6},
  pages={2697-705}
}
Dendritic cells are specialized APCs that exhibit an extraordinary capacity to activate naive T cells. Langerhans cells (LC), as epithelial tissue-specific members of this family, play key roles in the induction of T cell-mediated immunity against environmental, infectious, and tumor-associated Ags in skin. A major limitation in studying the biology of dendritic cells or LC has been the absence of stable, long-term cell lines. To overcome this limitation, we have established a series of APC… CONTINUE READING