Successful valganciclovir treatment of post-transplant cytomegalovirus infection in the presence of UL97 mutation N597D.

@article{Iwasenko2009SuccessfulVT,
  title={Successful valganciclovir treatment of post-transplant cytomegalovirus infection in the presence of UL97 mutation N597D.},
  author={Jenna M. Iwasenko and Gillian Marie Scott and William D Rawlinson and Anne Keogh and Daniel A. Mitchell and Sunwen Chou},
  journal={Journal of medical virology},
  year={2009},
  volume={81 3},
  pages={507-10}
}
Mutations in the human cytomegalovirus (CMV) UL97 protein kinase are the most common mechanism of ganciclovir (GCV) resistance in the clinical setting. A CMV strain with a previously unrecognized UL97 mutation N597D was identified in the blood of a heart transplant recipient who experienced a persistent CMV infection with high viral loads accompanying pain and fever while receiving valganciclovir (valGCV) therapy. The N597D mutation was transferred by mutagenesis to an antiviral sensitive CMV… CONTINUE READING

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