Successful use of iodine and levothyroxine to treat Graves' disease in a pregnant patient with allergy to antithyroid drugs and high thyrotropin-binding inhibitor immunoglobulin after radioiodine therapy.

@article{Kubota2005SuccessfulUO,
  title={Successful use of iodine and levothyroxine to treat Graves' disease in a pregnant patient with allergy to antithyroid drugs and high thyrotropin-binding inhibitor immunoglobulin after radioiodine therapy.},
  author={Sumihisa Kubota and Hidemi Ohye and Ichiro Sasaki and Eijun Nishihara and Takumi Kudo and Shuji Fukata and Nobuyuki Amino and Kanji Kuma and Nobuaki Mitsuda and Akira Miyauchi},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2005},
  volume={15 12},
  pages={
          1373-6
        }
}
High titer of thyrotropin-binding inhibitor immunoglobulin (TBII) in patients with Graves' disease can cause fetal hyperthyroidism during pregnancy. Prevention of fetal hyperthyroidism by administration of antithyroid drug (ATD) and levothyroxine (LT(4)) to pregnant patients who previously received ablative therapy has been reported. We administered iodine and LT(4) to a patient during gestation, because she had a severe adverse reaction to ATD. Although gestation proceeded normally, the infant… CONTINUE READING