Successful use of a reduced dose of protamine after cardiopulmonary bypass.

  title={Successful use of a reduced dose of protamine after cardiopulmonary bypass.},
  author={A V Guffin and R W Dunbar and Joel A. Kaplan and J W Bland},
  journal={Anesthesia and analgesia},
  volume={55 1},
The dose of protamine necessary to reverse heparin was examined in 60 patients. Half the patients (controls) received a reversal dose of protamine equal to the entire amount of heparin given them, while half received a reversal dose based on a heparin half-life of 2 hours. Postoperative chest drainage for the first 12 hours and for 48 hours was markedly reduced in patients given the reduced dose of protamine. Platelet counts were higher and postoperative clotting studies varied less from… CONTINUE READING

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