Successful treatment with tocilizumab in a case of Cogan's syndrome complicated with aortitis.

@article{Shibuya2013SuccessfulTW,
  title={Successful treatment with tocilizumab in a case of Cogan's syndrome complicated with aortitis.},
  author={Mihoko Shibuya and Keishi Fujio and Kaoru Morita and Hiroaki Harada and Hiroko Kanda and Kazuhiko Yamamoto},
  journal={Modern rheumatology},
  year={2013},
  volume={23 3},
  pages={577-81}
}
A 69-year-old man with sensorineural hearing loss and iritis was diagnosed with atypical Cogan's syndrome. He had several systematic manifestations: aortitis, meningitis, panniculitis and seronegative arthritis. Remission induced by treatment with high doses of prednisolone was followed by relapse within 1 year. Although his condition was resistant to various immunosuppressive drugs, including methotrexate, cyclosporine, azathioprine and adalimumab, his symptoms, inflammatory response and… CONTINUE READING