Successful treatment with Rituximab and Bendamustine in a patient with newly diagnosed Waldenström's Macroglobulinemia complicated by Bing-Neel syndrome.

@article{Varettoni2015SuccessfulTW,
  title={Successful treatment with Rituximab and Bendamustine in a patient with newly diagnosed Waldenstr{\"o}m's Macroglobulinemia complicated by Bing-Neel syndrome.},
  author={Marzia Varettoni and Enrico Marchioni and Maurizio Bonfichi and Anna Picchiecchio and Luca Arcaini and Carla Arbasino and Manuel Gotti and Matteo Da Vi{\`a} and Mariella Delmonte and Roberta Sciarra and Mario Cazzola},
  journal={American journal of hematology},
  year={2015},
  volume={90 8},
  pages={E152-3}
}
To the Editor: Bing-Neel syndrome (BNS), defined as central nervous system involvement from lymphoplasmacytic lymphoma/Waldenstrom’s Macroglobulinemia (WM), is a rare and usually late complication of the disease and is associated with a dismal prognosis. Treatment options for BNS include intrathecal chemotherapy, systemic chemotherapy (mainly with alkylating-based regimens or with purine analogs), and brain irradiation. The outcome reported with these treatments, often used in combination, is… CONTINUE READING