Successful treatment of valproic acid overdose with hemodialysis.

  title={Successful treatment of valproic acid overdose with hemodialysis.},
  author={Lindsev Johnson and I. Reinares Mart{\'i}nez and Miguel A. Carnero Fernandez and Clarence P. Davis and Balakuntalam S Kasinath},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  volume={33 4},
A 43-year-old woman took a large amount of depakote (divalproex, a slow-release form of valproate), became comatose, and developed severe hypotension refractory to fluid resuscitation and high-dose vasopressors. The serum valproic acid (VPA) concentration on admission was 1,380 microgram/mL (therapeutic range, 50 to 100 microgram/mL). She also had metabolic acidosis, thrombocytopenia, and normal renal and liver functions. Hemodialysis was initiated 4 hours after presentation. After 6 hours of… CONTINUE READING

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