Successful treatment of the idiopathic restless legs syndrome in a randomized double-blind trial of oxycodone versus placebo.

@article{Walters1993SuccessfulTO,
  title={Successful treatment of the idiopathic restless legs syndrome in a randomized double-blind trial of oxycodone versus placebo.},
  author={A. Walters and M. Wagner and W. Hening and K. Grasing and R. Mills and S. Chokroverty and N. Kavey},
  journal={Sleep},
  year={1993},
  volume={16 4},
  pages={
          327-32
        }
}
In a double-blind randomized crossover trial, oxycodone or placebo was given in divided night-time doses to 11 patients with idiopathic restless legs syndrome (RLS) for 2 weeks prior to appropriate polysomnographic studies. Under double-blinded conditions, patients were asked to do daily ratings of their leg sensations, motor restlessness and daytime alertness on a 1-4 scale for the 2 weeks prior to the polysomnographic studies and for the nights of the polysomnographic studies as well. Leg… Expand

Paper Mentions

Interventional Clinical Trial
The overall goal of this proposed study is to evaluate the underlying mechanisms of neural control of blood flow in the lower extremities in humans with restless leg syndrome (RLS). At… Expand
ConditionsNeuropathic Pain, Restless Legs Syndrome
InterventionBehavioral, Diagnostic Test, Other
Efficacy of pergolide in treatment of restless legs syndrome
Intractable restless legs syndrome: role of prolonged-release oxycodone–naloxone
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