Successful treatment of stage III neuroblastoma based on prospective biologic staging: a Children's Cancer Group study.

@article{Matthay1998SuccessfulTO,
  title={Successful treatment of stage III neuroblastoma based on prospective biologic staging: a Children's Cancer Group study.},
  author={Katherine K. Matthay and C Neyra P{\'e}rez and Robert C. Seeger and Garrett M. Brodeur and Hiroyuki Shimada and J. B. Atkinson and C. Thomas Black and Robert B. Gerbing and Gerald M. Haase and Daniel O. Stram and Patrick Swift and John Nicholas Lukens},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1998},
  volume={16 4},
  pages={1256-64}
}
PURPOSE To identify a biologically favorable and unfavorable subset of patients with Evans stage III neuroblastoma and to determine whether treatment stratification would improve the event-free survival (EFS) for high-risk patients and maintain excellent EFS for the lower-risk patients. PATIENTS AND METHODS Risk stratification was performed by age, MYCN gene copy number, Shimada histopathologic classification, and serum ferritin level. Lower-risk patients were treated on the less intensive… CONTINUE READING
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