BACKGROUND AND OBJECTIVES Tattoo removal can inadvertently lead to paradoxical darkening after laser procedure. We present a new laser device that may treat this unwanted outcome. STUDY DESIGN/PATIENTS AND METHODS We report two cases from a clinical trial, using a novel picosecond 532 nm and 1,064 nm laser to treat unwanted red tattoos. RESULTS Two cases of paradoxical darkening improved with the use of a novel picosecond 532 nm and 1,064 nm laser. CONCLUSION The use of a picosecond 532 nm and 1,064 nm laser may treat paradoxical darkening in red colored tattoos. Lasers Surg. Med. 48:471-473, 2016. © 2016 Wiley Periodicals, Inc.