Successful treatment of oesophageal candidiasis by micafungin: a novel systemic antifungal agent

@article{Pettengell2004SuccessfulTO,
  title={Successful treatment of oesophageal candidiasis by micafungin: a novel systemic antifungal agent},
  author={Keith Pettengell and J H Mynhardt and T McD Kluyts and Wendi M Lau and David P. Facklam and Donald N. Buell},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2004},
  volume={20}
}
Aim : To determine the minimum effective dose and safety of micafungin in the treatment of HIV‐related oesophageal candidiasis. 

A randomized, double blind, comparative trial of micafungin (FK463) vs. fluconazole for the treatment of oesophageal candidiasis

The objective of this study is to determine efficacy and safety of intravenous micafungin vs. intravenous fluconazole in the treatment of oesophageal candidiasis.

Developments in the treatment of candidiasis: more choices and new challenges

Systemic antifungal therapy can now be individualised based on the severity of the infection, comorbid conditions and the Candida spp.

Micafungin: an evidence-based review of its place in therapy

The first marketed echinocandin, micafungin, was approved in 2005 for the treatment of esophageal candidiasis and prophylaxis of invasive Candida infections in patients undergoing hematopoietic stem cell transplantation and has a favorable tolerability profile with no significant drug interactions and does not need adjustment for renal or hepatic insufficiency.

Micafungin: the US perspective

Micafungin holds promise as a first-line treatment option for candidiasis, as well as prophylaxis against invasive fungal infections during periods of neutropenia in high-risk patients.

[Scientific evidence supporting the use of micafungin in the treatment of invasive candidiasis].

Pharmacotherapy of Micafungin: Clinical Review

Micafungin, an echinocandin that inhibits the synthesis of 1,3-b-D glucan, an essential cell wall component of Candida species, has a very favorable safety profile with few adverse events and minimal drug-drug interactions.

Micafungin for candidiasis

The results from the largest studies of micafungin among patients with invasive and esophageal candidiasis are reviewed, and the use of echinocandins in this increasingly common disorder is supported.

Review of the pharmacology and clinical studies of micafungin

It is administered intravenously as a once daily infusion and does not require dose adjustments for renal or moderate hepatic dysfunction, and its safety record, favorable tolerability profile, and few drug interactions make it an important agent for the treatment of invasive fungal infections.

Micafungin: a review of its use in the prophylaxis and treatment of invasive Candida infections.

Micafungin is a valuable first-line or alternative option to other antifungal agents for the management of candidaemia and invasive candidiasis in adult and paediatric patients, including neonates, and as prophylaxis against fungal infections in patients undergoing HSCT.

Early Clinical Experience with Anidulafungin at a Large Tertiary Care Medical Center

It is suggested that early clinical experience with anidulafungin should be considered as an indication for further study to determine if it is safe and effective to treat central giant cell granuloma.
...

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