Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors.

Abstract

l -asparaginase (L-ase) is a major drug used to treat acute lymphoblastic leukemia (ALL) [1]. L-ase kills leukemic cells by depleting circulating asparagine pools related to its asparaginase activity [2]. L-ases from Escherichia coli and Erwinia chrysanthemi also degrade l -glutamine due to their glutaminase activity. Th e primary adverse eff ects of L-ase… (More)
DOI: 10.3109/10428194.2013.845886

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Cite this paper

@article{AlNawakil2014SuccessfulTO, title={Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors.}, author={Chadi Al-Nawakil and Lise Willems and C{\'e}dric Mauprivez and Benjamin Laffy and Mona Benm'rad and J{\'e}r{\^o}me Tamburini and H{\'e}l{\`e}ne Fontaine and Philippe Sogni and Beno{\^i}t Terris and Didier Bouscary and Laurence Moachon}, journal={Leukemia & lymphoma}, year={2014}, volume={55 7}, pages={1670-4} }