Corpus ID: 22102314

Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1.

@article{Mohammad1998SuccessfulTO,
  title={Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1.},
  author={R. Mohammad and M. Varterasian and V. P. Almatchy and G. N. Hannoudi and G. Pettit and A. Al-katib},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1998},
  volume={4 5},
  pages={
          1337-43
        }
}

R. Mohammad, M. Varterasian, +3 authors A. Al-katib

Published 1998

Biology, Medicine

Clinical cancer research : an official journal of the American Association for Cancer Research

We tested the activity of dolastatin 10 (a natural product derived from the shell-less marine mollusk, Dolabella auricularia, a sea hare) and its structural modification, auristatin PE, alone and in combination with bryostatin 1 (a protein kinase C activator derived from the marine bryozoan Bugula neritina) on a human B-cell chronic lymphocytic leukemia cell line (WSU-CLL) and in a severe combined immune deficient (SCID) mouse xenograft model bearing this cell line. WSU-CLL cells were cultured… CONTINUE READING

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