Successful treatment of cutaneous Langerhans cell histiocytosis with low‐dose methotrexate

  title={Successful treatment of cutaneous Langerhans cell histiocytosis with low‐dose methotrexate},
  author={A E Steen and Kay H. Steen and Ralf Bauer and Thomas Bieber},
  journal={British Journal of Dermatology},
Langerhans cell histiocytosis (LCH) can be a difficult therapeutic problem. We present a 40‐year‐old woman with a 4‐year history of LCH who was successfully treated with low‐dose methotrexate (20 mg weekly). 
Cutaneous Langerhans cell histiocytosis: study of Asian children shows good overall prognosis
To describe an Asian population with isolated cutaneous Langerhans cell histiocytosis (LCH), presenting a review on previous studies on this subgroup of patients and comparing our cohort with otherExpand
Langerhans cell histiocytosis first presenting in the skin in adults: frequent association with a second haematological malignancy
Background  Langerhans cell histiocytosis (LCH) in adults first presenting in the skin is rare. Guidelines for staging, treatment and follow‐up are lacking.
Diverse Cutaneous Presentations of Langerhans Cell Histiocytosis in Children: A Retrospective Cohort Study
Langerhans cell histiocytosis (LCH) is a rare disease, frequently affecting young children, and can be fatal in children under the age of five. Expand
Topical Imiquimod for the Treatment of Childhood Cutaneous Langerhans Cell Histiocytosis
A 16‐month‐old girl with isolated cutaneous LCH refractory to treatment with topical corticosteroids and topical tacrolimus is reported to highlight imiquimod as a novel therapeutic agent for the management of isolated cutaneously LCH in children. Expand
Adult Langerhans Cell Histiocytosis
Adult LCH patients are often evaluated by physicians who focus only on the most obviously affected organ without sufficient evaluation of other systems, which may lead to an erroneous diagnosis in some patients. Expand
An unusual case of intertrigo in an adult caused by purely cutaneous Langerhans cell histiocytosis
A case of persistent intertrigo in an adult, eventually diagnosed as cutaneous Langerhans cell histiocytosis (LCH), which is uncommon and usually other systems are affected. Expand
Topical Imiquimod for the Treatment of Relapsed Cutaneous Langerhans Cell Histiocytosis after Chemotherapy in an Elderly Patient
A 61-year-old female suffering from a refractory axillary ulcer for nearly a year, whose biopsy revealed LCH is reported, who was first successfully treated with multiagent chemotherapy and found topical imiquimod to be effective in the treatment of relapsed cutaneous LCH lesions. Expand
Langerhans cell histiocytosis in the jugular foramen.
The case of an adult patient with LCH affecting the jugular foramen is presented, and the relevant literature is reviewed. Expand
Successful treatment with cyclophosphamide of Langerhans cell histiocytosis involving the skin and lymph nodes in an adult patient
is a clear-cut demonstration of a differential expression pattern and subcellular localization of cell adhesion molecules, including strong N-cadherin expression and loss of b-catenin expression inExpand
[Langerhans cell histiocytosis].
Three syndromes are actually the same pathogenic process: eosinophilic granuloma (single or multiple osseous localizations), Hand-Schüller-Christian disease (chronic form with bone and visceral dissemination) and Abt-Letterer-Siwe disease (disseminated and acute malignant presentation). Expand


Langerhans cell histiocytosis of the skin.
  • S. Munn, A. Chu
  • Medicine
  • Hematology/oncology clinics of North America
  • 1998
It is important to recognize the wide spectrum of clinical disease that this disorder may adopt in the skin and to start with the simplest treatment and progress to systemic or interventional therapy as needed. Expand
Adult cutaneous Langerhans cell histiocytosis
A 24‐year‐old male presented with a 4 year history of a crusted erythematous popular eruption of the scalp and external auditory meati and a 12 month history of painful perianal ulceration, finding no systematic involvement. Expand
Prolonged response of multicentric reticulohistiocytosis to low dose methotrexate.
Graduated compression gloves produced an excellent cosmetic improvement in the disfiguring skin lesions in this case of multicentric reticulohistiocytosis complicated by central retinal vein thrombosis and trigeminal neuropathy. Expand
Pure cutaneous relapsing langerhans cell histiocytosis in an adult.
A case of recurrent class I histiocytosis with exclusive cutaneous localization in an adult having the same clinical evolution characterized by spontaneous resolution with scarring is reported. Expand
Severe multicentric reticulohistiocytosis: disease stabilization achieved with methotrexate and hydroxychloroquine.
A 56-year-old woman with erosive polyarthritis successfully treated exclusively for 30 months with hydroxychloroquine and methotrexate is described, suggesting this regimen may have the potential to provide longterm disease control with reduced risk of serious drug related toxicity. Expand
Complete remission of multicentric reticulohistiocytosis with combination therapy of steroid, cyclophosphamide, and low-dose pulse methotrexate. Case report, review of the literature, and proposal for treatment.
We describe a patient with multicentric reticulohistiocytosis in whom complete remission was achieved by sequential combination therapy with steroid, methotrexate, and cyclophosphamide. We reviewedExpand
Langerhans cell histiocytosis in the elderly: a report of three cases.
Biopsy specimens showed a dermal infiltrate abutting the epidermis composed of atypical langerhans cells with abundant eosinophilic cytoplasm and a "kidney-shaped" nucleus. Expand
Oral methotrexate and alternate-day prednisone for low-risk Langerhans cell histiocytosis.
It is concluded that oral chemotherapy with alternate-day PDN and weekly MTX is effective and non-toxic in patients with low-risk LCH. Expand
The confusing state of the histiocytoses
  • A. Chu
  • Medicine
  • The British journal of dermatology
  • 2000
The histiocytoses are reactive or malignant conditions in which various tissues, including the skin, are infiltrated by cells of the monocyte macrophage lineage. They are a heterogeneous group ofExpand
Langerhanszell-Histiozytose im Alter
A 73-year-old female patient with chronic stationary disease of 3,5 years duration died 4 weeks after the acute dissemination of her LCH, which is most frequent in children at the age of 1–3 years, seldomly seen in adults and extremely rare in the elderly. Expand