Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity.

@article{Kokkola2003SuccessfulTO,
  title={Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity.},
  author={Riikka Kokkola and Jun Li and Erik Sundberg and A-C Aveberger and Karin Palmblad and H. -S. Yang and Kevin J Tracey and Ulf Andersson and Helena Erlandsson Harris},
  journal={Arthritis and rheumatism},
  year={2003},
  volume={48 7},
  pages={2052-8}
}
OBJECTIVE Extracellular high mobility group box chromosomal protein 1 (HMGB-1) is a recently identified, endogenous, potent tumor necrosis factor- and interleukin-1 (IL-1)-inducing protein detectable in inflamed synovia in both human and experimental disease. In the present study, we examined clinical effects in collagen-induced arthritis (CIA) using therapeutic administration of neutralizing HMGB-1 antibodies or truncated HMGB-1-derived A-box protein, a specific, competitive antagonist of HMGB… CONTINUE READING

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