Successful treatment of IgM-mediated autoimmune hemolytic anemia with bortezomib.

  title={Successful treatment of IgM-mediated autoimmune hemolytic anemia with bortezomib.},
  author={Kenneth R. Carson and Lee G Beckwith and Jayesh Mehta},
  volume={115 4},
Chronic cold agglutinin disease (CAD) is an acquired autoimmune hemolytic anemia (AIHA); usually due to the production of a monoclonal immunoglobulin M (IgM) protein directed against polysaccharide antigens on red blood cells.1,2 An occult lymphoproliferative disorder is often responsible for the production of the IgM paraprotein in patients with symptomatic CAD.3 The discovery of an underlying neoplastic process does guide therapeutic decisions in patients with severe symptomatic CAD… CONTINUE READING


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  • Kenneth R. Carson, Lee G. Beckwith, Jayesh Mehta
  • Accessed September
  • 2008

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