Successful treatment of HTLV-1-related overlap syndrome using tacrolimus.

@article{Izumi2011SuccessfulTO,
  title={Successful treatment of HTLV-1-related overlap syndrome using tacrolimus.},
  author={Yasumori Izumi and Hiroshi Kojima and Yasushi Koga and Kazuaki Yokota and Hideki Mori and Tadayoshi Ohno and Taiichiro Miyashita and Masahiro Ito and Masakatsu Motomura and Masanobu Mine and Hironori Ezaki and Yuka Jiuchi and Daisuke Niino and Kouichi Ohshima and Kiyoshi Migita},
  journal={Internal medicine},
  year={2011},
  volume={50 17},
  pages={
          1849-53
        }
}
A 56-year-old HTLV-I-positive woman, initially diagnosed as having Sjögren's syndrome, presented with muscle weakness, myalgia, face erythema and leg edema. Based on the presence of various autoantibodies, the diagnosis of overlap syndrome (dermatomyositis/Sjögren's syndrome) was made. Treatment with high-dose corticosteroid plus cyclosporine improved her symptoms. However, three months after the start of these treatments, exacerbation of myositis occurred. A muscle biopsy revealed prominent… CONTINUE READING
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