Successful transplantation of haploidentically mismatched peripheral blood stem cells using CD133+-purified stem cells.

@article{Bitan2005SuccessfulTO,
  title={Successful transplantation of haploidentically mismatched peripheral blood stem cells using CD133+-purified stem cells.},
  author={Menachem Bitan and Michael Yechiel Shapira and Igor B. Resnick and Irina Zilberman and Svetlana Miron and Simcha Samuel and Aliza Ackerstein and Sharon Elad and Shosh Israel and Avraham Amar and Eitan Fibach and Reuven Or and Shimon Slavin},
  journal={Experimental hematology},
  year={2005},
  volume={33 6},
  pages={713-8}
}
OBJECTIVE For recipients of haploidentically mismatched stem cell allografts, T-cell depletion is mandatory to prevent lethal graft-vs-host disease (GVHD). Prevention of GVHD can be accomplished by negative selection of T cells or positive selection of stem cells. Recently, a new method for positive selection of stem cells was introduced using monoclonal antibodies against CD133 antigen. We report five cases of successful application of immunomagnetic separation of CD133+ stem cells for… CONTINUE READING