Successful therapy with calcium channel blocker (nifedipine) in persistent neonatal hyperinsulinemic hypoglycemia of infancy.

@article{Ba1999SuccessfulTW,
  title={Successful therapy with calcium channel blocker (nifedipine) in persistent neonatal hyperinsulinemic hypoglycemia of infancy.},
  author={Firdevs Baş and Feyza Darendeliler and Demet Demirkol and Ruveyde Bundak and Nurçin Saka and H{\"u}lya G{\"u}n{\"o}z},
  journal={Journal of pediatric endocrinology & metabolism : JPEM},
  year={1999},
  volume={12 6},
  pages={873-8}
}
The appropriate management of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) still remains controversial. Some patients show a response to treatment with diazoxide or somatostatin, but a number of children require total or near-total pancreatectomy to control hyperinsulinism. Recent studies suggest a dysfunction in the adenosine triphosphate-sensitive potassium channel present in the plasma membrane of pancreatic beta-cells in PHHI. The closure of these channels initiating the… CONTINUE READING