Successful silencing of plasminogen activator inhibitor-1 in human vascular endothelial cells using small interfering RNA.

@article{Hecke2006SuccessfulSO,
  title={Successful silencing of plasminogen activator inhibitor-1 in human vascular endothelial cells using small interfering RNA.},
  author={Anneke Hecke and Hilary Brooks and Matthieu Meryet-Figui{\`e}re and Stephanie Minne and Stavros V. Konstantinides and Gerd Hasenfuss and Bernard Lebleu and Katrin Sch{\"a}fer},
  journal={Thrombosis and haemostasis},
  year={2006},
  volume={95 5},
  pages={857-64}
}
Clinical as well as experimental evidence suggests that vascular overexpression of plasminogen activator inhibitor (PAI)-1, the primary physiological inhibitor of both urokinase and tissue-type plasminogen activator, may be involved in the pathophysiology of atherosclerosis and cardiovascular disease. We investigated the feasibility, efficacy and functional… CONTINUE READING