Successful pretreatment/therapy of soman, sarin and VX intoxication.

@article{Lennox1992SuccessfulPO,
  title={Successful pretreatment/therapy of soman, sarin and VX intoxication.},
  author={W. J. Lennox and L. W. Harris and D. R. Anderson and Richard P. Solana and Melanie L. Murrow and John V. Wade},
  journal={Drug and chemical toxicology},
  year={1992},
  volume={15 4},
  pages={
          271-83
        }
}
Chemical pretreatment is effective against a 2 LD50 challenge of soman, sarin or VX or a 5 LD50 challenge of tabun. Chemical pretreatment followed by post challenge therapy should be effective against greater levels of agent. Such tests in guinea pigs are reported here; pretreatment regimens (PRGs) consisted of physostigmine (0.15 mg/kg, im) and an adjunct. The adjuncts [mg/kg, im] used were aprophen [8], atropine (AT)[16], azaprophen (AZA)[5], benactyzine [1.25], benztropine (BT) [4… 
Experimental Therapeutics Against the Toxic and Lethal Effects Resulting from Acute Exposure to Nerve Agents Without Carbamate Pretreatment in Guinea Pigs
TLDR
The therapy mix used in this study was effective not only in antagonizing nerve agent-induced lethality, but also in protecting the functional integrity of the CNS and cardiorespiratory system.
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TLDR
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TLDR
Beagle dogs are used as an animal model with cholinergic sensitivity similar to that of humans to evaluate protection efficacy of continuous prophylactic administration of physostigmine and scopolamine against sarin‐induced toxicity.
Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioural effects of organophosphates in the common marmoset (Callithrix jacchus)
TLDR
A combination of physostigmine and scopolamine, which is known to protect against nerve-agent lethality, offers protection against the effects of soman and sarin on behavioural performance, as measured by a discrimination reversal task.
Continuous Administration of Low Dose Rates of Physostigmine and Hyoscine to Guinea‐pigs Prevents the Toxicity and Reduces the Incapacitation Produced by Soman Poisoning
  • J. Wetherell
  • Biology, Medicine
    The Journal of pharmacy and pharmacology
  • 1994
TLDR
Red cell acetylcholinesterase activity, 24 h after soman poisoning, was higher following continuous pretreatment with physostigmine and hyoscine than after acute treatment with atropine, and Hyoscine levels were higher in the cholinergic‐rich areas of the brain than in the plasma.
Low Concentrations of Pyridostigmine Prevent Soman-Induced Inhibition of GABAergic Transmission in the Central Nervous System: Involvement of Muscarinic Receptors
TLDR
Pyridostigmine bromide, acting via m3 receptors, can effectively counteract effects arising from the interactions of soman with m2 receptors in the brain.
Recent Developments in the Clinical Management of Weaponized Nerve Agent Toxicity
TLDR
This chapter reviews important advances in the clinical management of individuals exposed to nerve agents and discusses contingency management and alternate antidotes in the setting of mass depletion of existing antidote stock.
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TLDR
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