Successful preimplantation genetic diagnosis is related to the number of available cumulus-oocyte complexes.

@article{Vandervorst1998SuccessfulPG,
  title={Successful preimplantation genetic diagnosis is related to the number of available cumulus-oocyte complexes.},
  author={Mark Vandervorst and Inge Liebaers and Karen Dora Sermon and Cath{\'e}rine Staessen and Anick De Vos and Hilde van de Velde and Elvire van Assche and Hubert Joris and Andr{\'e} C. van Steirteghem and Paul Devroey},
  journal={Human reproduction},
  year={1998},
  volume={13 11},
  pages={3169-76}
}
The inheritance pattern of monogenic inheritable disorders influences the proportion of unaffected embryos after preimplantation genetic diagnosis (PGD). We aimed to investigate the influence of the number of cumulus-oocyte complexes (COC) on the outcome after PGD. Eighty-four cycles of 47 couples were included in our analysis. All couples were at risk of transmitting autosomal recessive, autosomal dominant, X-linked single gene disorders or sexaneuploidies to their offspring. One PGD cycle was… CONTINUE READING

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