Successful pre-transplant management of a patient with anti-factor H autoantibodies-associated haemolytic uraemic syndrome.

@article{Kwon2008SuccessfulPM,
  title={Successful pre-transplant management of a patient with anti-factor H autoantibodies-associated haemolytic uraemic syndrome.},
  author={Th{\'e}r{\'e}sa Kwon and Marie-Agn{\`e}s Dragon-Durey and M S Macher and V{\'e}ronique Baudouin and Anne Maisin and Michel Peuchmaur and V{\'e}ronique Fr{\'e}meaux-Bacchi and Chantal Loirat},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2008},
  volume={23 6},
  pages={2088-90}
}
Atypical haemolytic uraemic syndrome (aHUS) is known to be associated with mutations involving regulatory proteins of the complement alternative pathway, including factor H (CFH), factor I and MCP, in ∼50% of patients [1,2]. Eight patients have been reported with an acquired CFH deficiency because of the presence of anti-CFH autoantibodies [3,4]. These autoantibodies have been shown to influence the binding of CFH to the C3bBb convertase, thereby compromising CFH activity in vivo [3,4]. We now… CONTINUE READING

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