Successful outcome following allogeneic hematopoietic stem cell transplantation in adults with primary immunodeficiency.

@article{Fox2017SuccessfulOF,
  title={Successful outcome following allogeneic hematopoietic stem cell transplantation in adults with primary immunodeficiency.},
  author={Thomas A Fox and Ronjon K Chakraverty and Siobhan O. Burns and Benjamin T Carpenter and Kirsty J Thomson and David M Lowe and Adele K Fielding and Karl S. Peggs and Panagiotis D. Kottaridis and Benjamin J Uttenthal and Venetia Bigley and M Buckland and Victoria L Grandage and Shari Denovan and Sarah Grace and Julia Dahlstrom and Sarita Workman and Andrew Symes and Stephen Mackinnon and Rachael E Hough and Emma Morris},
  journal={Blood},
  year={2017},
  volume={131 8},
  pages={
          917-931
        }
}
The primary immunodeficiencies (PIDs), rare inherited diseases characterized by severe dysfunction of immunity, have been successfully treated by allogeneic hematopoietic stem cell transplantation (Allo-HSCT) in childhood. Controversy exists regarding optimal timing and use of Allo-HSCT in adults, due to lack of experience and previous poor outcomes. Twenty-nine consecutive adult patients, with a mean age at transplant of 24 years (range, 17-50 years), underwent Allo-HSCT. Reduced-intensity… CONTINUE READING
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