Successful management of antibody-mediated cardiac allograft rejection with combined immunoadsorption and anti-CD20 monoclonal antibody treatment: case report and literature review.

@article{Kaczmarek2007SuccessfulMO,
  title={Successful management of antibody-mediated cardiac allograft rejection with combined immunoadsorption and anti-CD20 monoclonal antibody treatment: case report and literature review.},
  author={Ingo Kaczmarek and M I Deutsch and Sebastian Sadoni and Paolo Brenner and Daniel Schmauss and Sabine H. Daebritz and Max Weiss and Bruno M. Meiser and B. W. Carney G. N. Cecil C. R. Evans H. J. Karwowski Reichart},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2007},
  volume={26 5},
  pages={511-5}
}
Chronic rejection is still the major limitation of long-term outcome of heart transplant recipients. Several recent studies demonstrated that a not negligible proportion of chronic allograft rejection episodes are not only mediated by T-cell response but also triggered by pre-transplant and de novo post-transplant donor-specific alloantibodies. This points at a fundamental role of humoral immune response mechanisms that contribute to early and late graft failure. This type of rejection is an… CONTINUE READING