Successful local regional therapy with topotecan of intraperitoneally growing human ovarian carcinoma xenografts.


The therapeutic effects of intraperitoneal topotecan, a water-soluble camptothecin analogue, were investigated in two models of human ovarian carcinoma xenografted intraperitoneally into nude mice: the IGROV-1 tumour, which originated from an untreated patient, and the A2780 tumour, selected for resistance in vitro to cisplatin (A2780DDP). In IGROV-1 tumour… (More)
DOI: 10.1038/bjc.1995.104


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