Successful isolation and expansion of CMV-reactive T cells from G-CSF mobilized donors that retain a strong cytotoxic effector function.

@article{Samuel2013SuccessfulIA,
  title={Successful isolation and expansion of CMV-reactive T cells from G-CSF mobilized donors that retain a strong cytotoxic effector function.},
  author={Edward R. Samuel and Katy Newton and Stephen Mackinnon and Mark W. Lowdell},
  journal={British journal of haematology},
  year={2013},
  volume={160 1},
  pages={87-100}
}
Cytomegalovirus (CMV) infections post-haematopoietic stem cell transplantation (HSCT) can be effectively controlled through the adoptive transfer of donor-derived CMV-specific T cells (CMV-T). Current strategies involve a second leukapheresis collection from the original donor to manufacture CMV-T, which is often not possible in the unrelated donor setting… CONTINUE READING