Successful isolated liver transplantation in a child with atypical hemolytic uremic syndrome and a mutation in complement factor H.

@article{Haller2010SuccessfulIL,
  title={Successful isolated liver transplantation in a child with atypical hemolytic uremic syndrome and a mutation in complement factor H.},
  author={W. Haller and David V. Milford and Timothy H. J. Goodship and Khalid Sharif and Darius Feroze Mirza and Patrick J Mckiernan},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2010},
  volume={10 9},
  pages={2142-7}
}
A male infant was diagnosed with atypical hemolytic uremic syndrome (aHUS) at the age of 5.5 months. Sequencing of the gene (CFH) encoding complement factor H revealed a heterozygous mutation (c.3644G>A, p.Arg1215Gln). Despite maintenance plasmapheresis he developed recurrent episodes of aHUS and vascular access complications while maintaining stable renal function. At the age of 5 years he received an isolated split liver graft following a previously established protocol using pretransplant… CONTINUE READING