Successful intensive insulin treatment of type 1 diabetic dogs leads to restoration of peripheral leukocyte insulin signaling gene expression and enzyme activities.

@article{Mori2009SuccessfulII,
  title={Successful intensive insulin treatment of type 1 diabetic dogs leads to restoration of peripheral leukocyte insulin signaling gene expression and enzyme activities.},
  author={Akihiro Mori and Peter Lee and Toshinori Sako and Hisashi Mizutani and Toshiro Arai},
  journal={The Journal of veterinary medical science},
  year={2009},
  volume={71 8},
  pages={1017-26}
}
The purpose of this study was to investigate whether intensive insulin treatment of dogs suffering from type 1 diabetes mellitus, resulting in tight glycemic control, could be reflected by changes in peripheral leukocyte metabolism. Specifically, plasma metabolites and enzyme activities were assessed. In addition, quantitative RT-PCR was used to determine… CONTINUE READING