Successful inactivation of endogenous Oct-3/4 and c-mos genes in mouse preimplantation embryos and oocytes using short interfering RNAs.

@article{Kim2002SuccessfulIO,
  title={Successful inactivation of endogenous Oct-3/4 and c-mos genes in mouse preimplantation embryos and oocytes using short interfering RNAs.},
  author={Mi-Hyun Kim and Xunmei Yuan and Sayaka Okumura and Fuyuki Ishikawa},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={296 5},
  pages={1372-7}
}
Understanding oocyte maturation and early development in mammals is very important, especially because these cells serve as a source of materials useful in medical applications, such as ES cells. However, the limited availability of oocytes and embryos hampers the molecular dissection of the very early stage of mammalian development. Recently, the RNA interference technology has been acknowledged to be very effective and useful in diverse groups of cells, including mammalian cells. In this… CONTINUE READING

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