Successful in vitro fertilization and generation of transgenics in Black and Tan Brachyury (BTBR) mice

Abstract

The Black and Tan Brachyury (BTBR) mouse strain is a valuable model for the study of long-term complications from obesity-induced type 2 diabetes mellitus and autism spectrum disorder. Due to technical difficulties with assisted reproduction, genetically modified animals on this background have previously been generated through extensive backcrossing, which… (More)
DOI: 10.1007/s11248-016-9974-0

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