Successful implementation of a national HLA-B*5701 genetic testing service in Canada.

@article{Lalonde2010SuccessfulIO,
  title={Successful implementation of a national HLA-B*5701 genetic testing service in Canada.},
  author={Richard Lalonde and Rasmi Thomas and Anita Rochelle Rachlis and Michael J. Gill and M. Roger and Jonathan Angel and Gr{\'e}goire Smith and Niamh Higgins and Benoit Trottier},
  journal={Tissue antigens},
  year={2010},
  volume={75 1},
  pages={
          12-8
        }
}
Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) that is used in combination antiretroviral therapy in HIV-infected patients. It is currently recommended as a preferred or an alternative NRTI in antiretroviral-naïve patients. The major toxicity of abacavir is a hypersensitivity reaction (HSR), which occurs in approximately 5% of treated patients. There is a strong association between the human leukocyte antigen (HLA)-B*5701 allele and abacavir HSR, which has allowed for rapid… CONTINUE READING
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