To the Editors: The life expectancy of HIV-infected patients has increased with highly active antiretroviral therapy (HAART), and in 2005, 24% of individuals living with HIV/AIDS in the United States were aged 50 years and older. It is projected that by 2015, more than half of the HIV-infected adults in the United States will be >50 years old. With increasing life expectancy in developed nations, the United Nations currently defines elderly as older than 60 years of age. Only a few studies have reported on older HIV-infected adults and there are sparse data reported on HIV infection in patients 60 years of age or older. The Ruth M. Rothstein CORE Center (CORE Center) provides comprehensive outpatient care to individuals with HIV/AIDS, and of the more than 4500 HIV-infected adults who receive care at the CORE center, 27% are over the age of 50. In a small study published from our group in 2003, we identified 83 patients $60 years of whom 56 (65%) were still active in care and included in this study. The objectives of the present study were to describe the immunologic and virologic long-term outcomes of patients aged 60 years or older and to determine if these outcomes differed by age at HIV diagnosis.