Successful histocompatible myoblast transplantation in dystrophin- deficient mdx mouse despite the production of antibodies against dystrophin

@article{Vilquin1995SuccessfulHM,
  title={Successful histocompatible myoblast transplantation in dystrophin- deficient mdx mouse despite the production of antibodies against dystrophin},
  author={Jean Thomas Vilquin and Ernst Wagner and Ikuo Kinoshita and Roopali Roy and Jacques Pierre Tremblay},
  journal={The Journal of Cell Biology},
  year={1995},
  volume={131},
  pages={975 - 988}
}
Myoblast transplantation has been considered a potential treatment for some muscular disorders. It has proven very successful, however, only in immunodeficient or immunosuppressed mice. In this study, myoblasts from C57BL10J +/+ mice were transplanted, with no immunosuppressive treatment, in the tibialis anterior of fully histocompatible but dystrophin-deficient C57BL10J mdx/mdx mice. One to 9 months after transplantation, the success of the graft was evaluated by immunohistochemistry. All the… CONTINUE READING