Successful graft-versus-host disease prevention without graft failure in 32 HLA-identical allogeneic bone marrow transplantations with marrow depleted of T cells by monoclonal antibodies and complement.

@article{Herve1987SuccessfulGD,
  title={Successful graft-versus-host disease prevention without graft failure in 32 HLA-identical allogeneic bone marrow transplantations with marrow depleted of T cells by monoclonal antibodies and complement.},
  author={Philippe J. L. Herve and Jean Yves Cahn and Markus Flesch and Emanuel Plouvier and Evelyne Racadot and A Noir and Y. Couteret and G. Goldstein and Anne-Marie Bernard and R Lenys},
  journal={Blood},
  year={1987},
  volume={69 2},
  pages={388-93}
}
Thirty-two patients with acute leukemia, chronic granulocytic leukemia, or multiple myeloma received a T lymphocyte-depleted HLA-identical marrow. After being treated with pan-T monoclonal antibodies (MoAbs) and one round of baby rabbit complement, the mean percentage of T cell depletion was 94% +/- 4%. The number of residual viable T cell infused to the patient was 0.99 +/- 0.65 X 10(6) per kg body weight. The patients were conditioned with fractionated total body irradiation (TBI) (12 Gy… CONTINUE READING