Successful ganciclovir therapy in a patient with human herpesvirus-6 encephalitis after unrelated cord blood transplantation: usefulness of longitudinal measurements of viral load in cerebrospinal fluid

@article{Hirabayashi2012SuccessfulGT,
  title={Successful ganciclovir therapy in a patient with human herpesvirus-6 encephalitis after unrelated cord blood transplantation: usefulness of longitudinal measurements of viral load in cerebrospinal fluid},
  author={Kanae Hirabayashi and Yuta Nakazawa and Yosuke Katsuyama and Tetsuya Taga Yanagisawa and Satoko Saito and Kentaro Yoshikawa and Tomonari Shigemura and Kazuo Sakashita and Marie Ichikawa and Kaoru Koike},
  journal={Infection},
  year={2012},
  volume={41},
  pages={219-223}
}
There have been no reports of human herpesvirus-6 (HHV-6) encephalitis treatment based on both HHV-6 DNA load and the antiviral agent’s concentration in the cerebrospinal fluid (CSF). A 20-year-old male with a hematological malignancy developed HHV-6 encephalitis 15 days after unrelated cord blood transplantation (UCBT). He had fever, chest pain, memory impairment, and insomnia. His CSF showed no increased cell counts, but the amount of HHV-6 DNA was elevated to 2.0 × 106 copies/ìgDNA. Magnetic… CONTINUE READING

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