Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum.

@article{Aversa1994SuccessfulEO,
  title={Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum.},
  author={Franco Aversa and Antonio Tabilio and Adelmo Terenzi and Andrea Velardi and Franca Falzetti and Claudia Giannoni and R Iacucci and Tiziana Zei and Maria Paola Martelli and Cristiana Gambelunghe},
  journal={Blood},
  year={1994},
  volume={84 11},
  pages={3948-55}
}
Patients who undergo transplantation with haploidentical "three-loci" mismatched T-cell-depleted bone marrow (BM) are at high risk for graft failure. To overcome the host-versus-graft barrier, we increased the size of the graft inoculum, which has been shown to be a major factor in controlling both immune rejection and stem cell competition in murine models. Seventeen patients (mean age, 23.2 years; range, 6 to 51 years) with end-stage chemoresistant leukemia were received transplants of a… CONTINUE READING

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