Successful early rituximab treatment in a case of systemic lupus erythematosus with potentially fatal diffuse alveolar hemorrhage.

@article{Na2015SuccessfulER,
  title={Successful early rituximab treatment in a case of systemic lupus erythematosus with potentially fatal diffuse alveolar hemorrhage.},
  author={Ju Ock Na and Sung Hae Chang and K Seo and Jae Sung Choi and Ho Sung Lee and Ji Won Lyu and Seoung-Su Nah},
  journal={Respiration; international review of thoracic diseases},
  year={2015},
  volume={89 1},
  pages={62-5}
}
Diffuse alveolar hemorrhage (DAH) is a rare but devastating complication of systemic lupus erythematosus (SLE) with a high early mortality rate. DAH seldom occurs without active organ involvement. Recently, rituximab (RTX), a B cell-targeted therapy, has been reported to be effective for life-threatening autoimmune diseases. We describe a SLE patient who presented with acute respiratory failure due to DAH without other active organ involvement. This condition was dramatically improved with RTX… CONTINUE READING