• Corpus ID: 33034093

Successful colonoscopic fecal transplant for severe acute Clostridium difficile pseudomembranous colitis.

  title={Successful colonoscopic fecal transplant for severe acute Clostridium difficile pseudomembranous colitis.},
  author={Juan Fernando Gallegos-Orozco and C D Paskvan-Gawryletz and Suryakanath R. Gurudu and Robert Michael Orenstein},
  journal={Revista de gastroenterologia de Mexico},
  volume={77 1},
Clostridium difficile-associated diarrhea has become one of the most common healthcare-associated infections, with significant morbidity and mortality, especially among the elderly in the inpatient setting. The standard approach with metronidazole and vancomycin is not very effective in treating patients with severe colitis and hence other alternatives have been explored. We herein describe the first successful experience of colonoscopic fecal transplant in a case of severe refractory C… 
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A case of faecal microbiota transplantation used for severe binary toxin-positive Clostridium difficile infection in an intensive care setting is described and adjunctive therapy with FMT given through gastroscopy resulted in resolution of the C.difficile-related symptoms.
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As hypervirulent strains evade conventional drug therapies, investment in FMT becomes a viable alternative and specific advantages of the approach over conventional treatment are its relative efficacy and cost effective ness.
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Fecal microbiota transplantation for the management of Clostridium difficile infection.
The efficacy of intracolonic vancomycin for severe Clostridium difficile colitis: a case series
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Fecal microbiota transplantation for the treatment of Clostridium difficile infection.
Patients with inflammatory bowel disease (IBD) who undergo FMT for CDI may be at increased risk of IBD flare, and caution should be exercised with use of FMT in that population, and rigorously conducted prospective studies are needed.
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Epidemiology, Diagnosis, and Management of Clostridium difficile Infection in Patients with Inflammatory Bowel Disease
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Elevated fecal calprotectin associates with adverse outcomes from Clostridium difficile infection in older adults
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Success of self-administered home fecal transplantation for chronic Clostridium difficile infection.
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  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2010
Intravenous immunoglobulin for resistant Clostridium difficile infection.
This treatment may compensate for a failed immune response to CD toxin and should be considered for relapsing CD-associated diarrhoea where there is no response to conventional treatment strategies.
Intravenous tigecycline as adjunctive or alternative therapy for severe refractory Clostridium difficile infection.
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    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2009
4 patients with severe refractory CDI who were successfully treated with tigecycline were described, and symptoms improved within 1 week and no relapses were observed.
Treatment of Refractory/Recurrent C. difficile-associated Disease by Donated Stool Transplanted Via Colonoscopy: A Case Series of 12 Patients
Fecal transplantation via colonoscopy is a safe, effective treatment regimen for refractory/recurrent Clostridium difficile-associated disease and its use and efficacy should be pursued in prospective controlled trials.
Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube.
  • J. Aas, C. Gessert, J. Bakken
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2003
Patients with recurrent C. difficile colitis may benefit from the introduction of stool from healthy donors via a nasogastric tube, according to retrospectively reviewed medical records.
Faecal transplant for recurrent Clostridium difficile-associated diarrhoea: a UK case series.
Faecal transplantation via a nasogastrically administered faecal tube could be considered in patients with refractory relapsing CDAD and is an effective and safe treatment for recurrent CDAD.
Results of faecal donor instillation therapy for recurrent Clostridium difficile-associated diarrhoea
In the experience the procedure is easy to perform, well tolerated, effective, and may be a valuable treatment option in selected cases.
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Successful treatment of fulminant Clostridium difficile infection with fecal bacteriotherapy.