Esophageal perforation is a rare complication of transesophageal echocardiography with an incidence of 0.01%–0.3% . In October 2011, a 56-year-old woman underwent a lung transplant for nonspecific interstitial pneumonia. Postoperatively, whilst receiving triple immunosuppression, her C-reactive protein (CRP) started to rise steadily and she developed atrial fibrillation, septic shock, and renal insufficiency. After 26 days, she was found to have a pneumopericardium on computed tomography (CT; ●" Fig.1). An upper gastrointestinal endoscopy performed after a bronchopericardial fistula had been excluded showed a fistula in the middle third of the esophagus (●" Fig.2a). As this was close to the left atrium, it was suspected that a transesophageal echocardiogram was the cause. The pericardium was fenestrated and a drain inserted. After this, a self-expanding metal stent (SEMS) was deployed (Ultraflex, 12cm× 23/28mm; Boston Scientific, Natick, Massachusetts, USA). Having recovered from the septic shock, the patient underwent removal of the stent 2 weeks later. Because the perforation was still present, an over-the-scope clip (OTSC; 11/3a; Ovesco Endoscopy, Tübingen, Germany) was applied (●" Fig.2b, c). Closure of the perforation was demonstrated by a CT scan that showed no leakage of oral contrast (●" Fig.3). After 6 days the pericardial drainwas removed and ongoing closure was confirmed by a further CT scan with oral contrast. After 4 weeks the patient was receiving oral nutrition with no signs of inflammation or pericardial effusion. The outcome of esophageal perforation is strongly influenced by early diagnosis and treatment. Small lesions can be managed conservatively, but nowadays most perforations are initially treated by insertion of covered SEMSs , although nearly half of the patients will need a second stent inserted subsequently. The insertion of a percutaneous, thoracoscopic, or even open surgical drain into the mediastinum improves the likelihood of sealing the perforation because it empties the cavity of secretions and provides an extrinsic cover for the perforation site . Successful closure of esophageal perforations with endoclips has been previously reported [4,5], as has the successful sealing of leaks with OTSCs .