Successful allotransplantation of mouse pancreatic islets to nonimmunosuppressed recipients.

@article{Bowen1980SuccessfulAO,
  title={Successful allotransplantation of mouse pancreatic islets to nonimmunosuppressed recipients.},
  author={Kathy Bowen and Lucius B. Andrus and Kevin J. Lafferty},
  journal={Diabetes},
  year={1980},
  volume={29 Suppl 1},
  pages={98-104}
}
Pancreatic islets from BALB/c (H-2d) mice are rejected within 14 days of transplantation to the kidney capsule of allogeneic, CBA/H (H-2k) recipients. Cyclophosphamide pretreatment of the islet donor reduced the intensity of the allograft response, and these islets undergo a more chronic rejection process. Islets from cyclophosphamide-pretreated donors can be cultured in a gas phase of 95% O2 and 5% CO2, provided the islets are aggregated into clusters of about 50 islets. After a culture period… CONTINUE READING

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