Successful Use of Intravenous Dexmedetomidine for Magnetic Resonance Imaging Sedation in Autistic Children

@article{Ahmed2014SuccessfulUO,
  title={Successful Use of Intravenous Dexmedetomidine for Magnetic Resonance Imaging Sedation in Autistic Children},
  author={Sheikh Sohail Ahmed and Tamara Unland and James E. Slaven and Mara E. Nitu and Mark Rigby},
  journal={Southern Medical Journal},
  year={2014},
  volume={107},
  pages={559–564}
}
Objectives Autism and autism spectrum disorders (A/ASD) represent a family of neurodevelopmental conditions that are associated with overactive, difficult-to-control behaviors. Sedating these patients for magnetic resonance imaging (MRI) poses challenges. Children with A/ASD were examined against clinical controls to determine the effectiveness and safety of intravenous (IV) dexmedetomidine for deep sedation. Methods The quality assurance data on all of the children who received IV… 

Figures and Tables from this paper

Commentary on "Successful use of intravenous dexmedetomidine for magnetic resonance imaging sedation in autistic children".
  • J. Lumeng
  • Medicine, Psychology
    Southern medical journal
  • 2014
TLDR
It was found that children with ASD could be sedated for MRI successfully using dexmedetomidine and there was no evidence of increased prevalence of relatively common adverse effects among the group with ASD as compared with controls.
A Comparison of Safety and Efficacy of Dexmedetomidine and Propofol in Children with Autism and Autism Spectrum Disorders Undergoing Magnetic Resonance Imaging
TLDR
Both propofol and dexmedetomidine proved to be adequate and safe medications in the sedation of autistic children undergoing MRI.
Outpatient Procedural Sedation of Patients With Autism Spectrum Disorders for Magnetic Resonance Imaging of the Brain Using Propofol
TLDR
Children with ASD can be sedated for brain MRI using propofol with no increased frequency of SAEs compared with children without ASD, but Sedation teams should anticipate that 10% of children with ASD may need additional personnel before prop ofol induction.
Endovenous Dexmedetomidine in Pediatric Patient with Autism Spectrum Disorder Undergoing General Anesthesia
TLDR
There appears to be little literature in paediatric anaesthetic practice relevant to children suffering with autism, and recent findings suggest a need for rigorous study of the potential problems that autistic children may have when undergoing an anaesthetic.
ASSESSMENT OF BLOOD GLUCOSE LEVELS AND SEVOFLURANE REQUIREMENT IN PATIENTS ON DEXMEDETOMIDINE INFUSION FOR INTRA-PERITONEAL SURGERIES
  • Krishna Kumar
  • Medicine
    International Journal of Medical and Biomedical Studies
  • 2018
TLDR
The data generated in the two study groups in the present study concludes that the use of dexmedetomidine maintains blood glucose levels and favourably influencing the intra operative stress inducedBlood glucose levels.
Perioperative considerations in children with autism spectrum disorder
TLDR
Patients with autism spectrum disorder are a heterogeneous group and often need general anesthesia for different procedures and studies, so familiarity with each patient's behavioral specifics and efforts to alleviate stress is of paramount importance for a smooth perioperative course with minimal adverse events.
Randomized comparison between dexmedetomidine–remifentanil and midazolam–fentanyl for deep sedation during catheter ablation of atrial fibrillation
TLDR
The combined use of dexmedetomidine and remifentanil provides higher stability sedation during AF ablation, but can lead to more frequent hemodynamic compromise compared to midazolam and fentanyl.
A systematic review of person-centred adjustments to facilitate magnetic resonance imaging for autistic patients without the use of sedation or anaesthesia
TLDR
Customising communication was found to be a key adjustment, as well as scan-based optimisation and environmental adaptations, which can be used to make suggestions on how to improve magnetic resonance imaging practice and the autistic patient experience.
A prospective, randomised double-blind study on the anaesthetic effect of dexmedetomidine hydrochloride in brainstem tumour surgery
TLDR
Dexmedetomidine hydrochloride has a good analgesic effect in intraoperative anaesthesia during brainstem tumour surgery, which significantly reduces the incidence of adverse reactions, and is worthy of clinical popularisation and application.
...
1
2
...

References

SHOWING 1-10 OF 43 REFERENCES
Dexmedetomidine for Pediatric Sedation for Computed Tomography Imaging Studies
TLDR
Based on the pilot results, dexmedetomidine may provide a reliable and effective method of providing sedation in the pediatric population.
Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results.
TLDR
Dexmedetomidine provided adequate sedation in most of the children aged 1-7 yr without haemodynamic or respiratory effects during MRI procedures, and the quality of MRI was significantly better.
Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children*
  • J. Berkenbosch, P. Wankum, J. Tobias
  • Medicine
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2005
Objective: Children often require sedation for lengthy noninvasive procedures. Conventional agents such as chloral hydrate, benzodiazepines, or barbiturates have been associated with sedation
EEG Sedation for Children with Autism
TLDR
Clonidine is a viable alternative for sedation in children with autism and PDD and is well tolerated without any significant side effects and is efficacious in childrenwith autism andPDD.
A Comparison of the Sedative, Hemodynamic, and Respiratory Effects of Dexmedetomidine and Propofol in Children Undergoing Magnetic Resonance Imaging
TLDR
It is concluded that although propofol provided faster anesthetic induction and recovery times, it caused hypotension and desaturation and dexmedetomidine could be an alternative reliable sedative drug to prop ofol in selected patients.
Clinical Uses of Dexmedetomidine in Pediatric Patients
TLDR
The literature suggests potential use of dexmedetomidine as an adjunctive agent to other sedatives during mechanical ventilation and opioid/benzodiazepine withdrawal and its efficacy was highest during non-invasive procedures, and lowest during invasive procedures, such as cardiac catheterization.
Sedatives used in pediatric imaging: comparison of IV pentobarbital with IV pentobarbital with midazolam added.
TLDR
The prolonged time needed both to sedate and to discharge (timed from the initial dose of sedation) pediatric patients who have received midazolam should discourage physicians from combining it with pentobarbital for pediatric sedation.
Additional Experience with Dexmedetomidine in Pediatric Patients
TLDR
Preliminary data suggest that dexmedetomidine may be an effective agent for sedation in spontaneously breathing patients, in the treatment of drug withdrawal, and in the Treatment of two common postanesthesia problems.
Sedative, Amnestic, and Analgesic Properties of Small-Dose Dexmedetomidine Infusions
TLDR
Small-dose dexmedetomidine infusions resulted in reversible sedation, mild analgesia, and memory impairment without cardiorespiratory compromise, and these properties might prove useful in a postoperative or intensive care unit setting.
...
1
2
3
4
5
...