Successful Treatment with Peginterferon alfa-2b of HBeAg-positive HBV Non-Responders to Standard Interferon or Lamivudine

@article{Flink2006SuccessfulTW,
  title={Successful Treatment with Peginterferon alfa-2b of HBeAg-positive HBV Non-Responders to Standard Interferon or Lamivudine},
  author={Hajo J. Flink and Bettina E Hansen and Elizabeth Jenny Heathcote and S. Victor Feinman and Halis Şimşek and Selim Karayalçin and Tomasz H. Mach and Wim F Leemans and Robert A. De Man and E. R. Verhey and Solko W. Schalm and Harry L. A. Janssen},
  journal={The American Journal of Gastroenterology},
  year={2006},
  volume={101},
  pages={2523-2529}
}
OBJECTIVES:Antiviral therapy leads to HBeAg seroconversion in 10–40% of the patients with HBeAg-positive chronic hepatitis B. Nonresponse may result in progression of liver disease and increased risk of hepatocellular carcinoma. As part of a global randomized controlled trial we investigated the efficacy (i.e., loss of HBeAg at the end of follow-up) of peginterferon alfa-2b (Peg-IFN α2b) in patients who failed to respond to previous courses of standard interferon (IFN) or lamivudine.METHODS:We… CONTINUE READING

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