Successful Translation of Pharmacogenetics into the Clinic

@article{Phillips2012SuccessfulTO,
  title={Successful Translation of Pharmacogenetics into the Clinic},
  author={Elizabeth Phillips and S. Mallal},
  journal={Molecular Diagnosis & Therapy},
  year={2012},
  volume={13},
  pages={1-9}
}
  • Elizabeth Phillips, S. Mallal
  • Published 2012
  • Medicine
  • Molecular Diagnosis & Therapy
  • Abacavir hypersensitivity syndrome (AHS) is a potentially life-threatening illness occurring in 4–8% of those initiating the drug. Early studies identified a strong association between the MHC class I allele HLA-B*5701 and AHS. These studies suggested that HLA-B*5701 holds promise as a screening test to prevent AHS, but concern arose from HLA-B*5701-negative cases with a clinical diagnosis of AHS, and particularly from early reports of apparently low sensitivities of HLA-B*5701 for AHS in… CONTINUE READING
    41 Citations

    Paper Mentions

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