Successful Translation of Pharmacogenetics into the Clinic

  title={Successful Translation of Pharmacogenetics into the Clinic},
  author={Elizabeth Phillips and S. Mallal},
  journal={Molecular Diagnosis & Therapy},
  • Elizabeth Phillips, S. Mallal
  • Published 2012
  • Medicine
  • Molecular Diagnosis & Therapy
  • Abacavir hypersensitivity syndrome (AHS) is a potentially life-threatening illness occurring in 4–8% of those initiating the drug. Early studies identified a strong association between the MHC class I allele HLA-B*5701 and AHS. These studies suggested that HLA-B*5701 holds promise as a screening test to prevent AHS, but concern arose from HLA-B*5701-negative cases with a clinical diagnosis of AHS, and particularly from early reports of apparently low sensitivities of HLA-B*5701 for AHS in… CONTINUE READING
    41 Citations

    Paper Mentions

    Blog Post
    Direct PCR: a new pharmacogenetic approach for the inexpensive testing of HLA-B*57:01
    • 16
    • PDF
    Drug hypersensitivity in HIV infection.
    • 6
    Delabeling Delayed Drug Hypersensitivity: How Far Can You Safely Go?
    • 2


    Genetic characterization of patients with MHC class I mediated abacavir hypersensitivity reaction
    • 10
    Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
    • A. Martin, D. Nolan, +9 authors S. Mallal
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2004
    • 420
    • PDF
    Genetic screening to prevent abacavir hypersensitivity reaction: are we there yet?
    • E. Phillips
    • Medicine
    • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
    • 2006
    • 74
    • PDF
    A sensitive and rapid alternative to HLA typing as a genetic screening test for abacavir hypersensitivity syndrome
    • 46
    Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations.
    • 233
    Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
    • 741
    First large, multicenter, open-label study utilizing HLA-B*5701 screening for abacavir hypersensitivity in North America
    • 73
    • Highly Influential