Successful Therapy Reduction and Intensification for Childhood Acute Lymphoblastic Leukemia Based on Minimal Residual Disease Monitoring: Study ALL10 From the Dutch Childhood Oncology Group.

@article{Pieters2016SuccessfulTR,
  title={Successful Therapy Reduction and Intensification for Childhood Acute Lymphoblastic Leukemia Based on Minimal Residual Disease Monitoring: Study ALL10 From the Dutch Childhood Oncology Group.},
  author={Rob Pieters and Hester A. de Groot-Kruseman and Vincent H J van der Velden and Marta Fiocco and Henk van den Berg and Evelien de Bont and R. Maarten Egeler and Peter Hoogerbrugge and Gertjan J L Kaspers and Ellen van der Schoot and V. de Haas and Jacques van Dongen},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2016},
  volume={34 22},
  pages={
          2591-601
        }
}
PURPOSE Outcome of childhood acute lymphoblastic leukemia (ALL) improved greatly by intensifying chemotherapy for all patients. Minimal residual disease (MRD) levels during the first months predict outcome and may select patients for therapy reduction or intensification. METHODS Patients 1 to 18 years old with ALL were stratified on the basis of MRD levels after the first and second course of chemotherapy. Thereafter, therapy was substantially reduced in patients with undetectable MRD… CONTINUE READING
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