Successful Heart Transplantation for Unreversible Endomyocardial Fibrosis Related to FIP1L1-PDGFRA Chronic Eosinophilic Leukemia.

  title={Successful Heart Transplantation for Unreversible Endomyocardial Fibrosis Related to FIP1L1-PDGFRA Chronic Eosinophilic Leukemia.},
  author={F. Fassnacht and Mathilde Roumier and Pierre Jean Fouret and Vincent Lévy and Shaida Varnous and St{\'e}phanie Russel and Guillaume Lef{\`e}vre and Jean-Emmanuel Kahn},
  volume={99 11},
Endomyocardial fibrosis (EMF) is estimated to be the most frequent worldwide cause of restrictive cardiomyopathy with impaired filling of 1 or both ventricles caused by deposition of fibrous tissue on endocardial surfaces. The etiology is still unknown, but allergy, malnutrition, helminthic infestations, cardiotropic virus, and toxic agents have been related to EMF. The main causes of nontropical EMF are eosinophilic granulomatosis with polyangiitis (or ChurgStrauss) and hypereosinophilic… Expand
5 Citations
Endomyocardial Fibrosis With End-Stage Heart Failure as a Consequence of a Myeloproliferative Neoplasm With Hypereosinophilia.
The case of a middle-aged man diagnosed with a myeloproliferative neoplasm associated with hypereosinophilia and treated with imatinib is described and this disease might not be considered a contraindication for heart transplantation. Expand
Speckle tracking and global longitudinal strain in endomyocardial infiltration during FIP1L1-PDGFRA chronic eosinophilic leukaemia.
This is the second report on the use of speckle tracking echocardiography in chronic eosinophilic leukaemia with cardiac involvement and similarities in distribution of disturbed myocardial strain and reduced global longitudinal strain are evident. Expand
Morphologically proved ANCA positive Loeffler's pancarditis: medical and surgical treatment.
Signs of active inflammation with single eosinophils, vasculitis, perimuscular sclerosis, endocardial sclerosis were detected in morphological and immunohistochemical studies of endo-, myo-, pericardium. Expand
Epidemiology, clinical picture and long‐term outcomes of FIP1L1‐PDGFRA‐positive myeloid neoplasm with eosinophilia: Data from 151 patients
In F/P+ MN‐eo, prompt initiation of IM and longer treatment durations may prevent relapses after discontinuation of IM, which is highly efficient but no predictive factor of relapse after discontinisation has yet to be identified. Expand
Physiology and pathology of eosinophils: Recent developments
In a 2‐day focus workshop of the German Society for Allergology and Clinical Immunology (DGAKI), the state of the art was discussed and practical recommendations for diagnosis and treatment of eosinophilic diseases, with a particular focus on new biologics, such as anti‐interleukin 5 and anti‐interspecies 5R, were derived. Expand


Rapid Reversion of Loeffler's Endocarditis by Imatinib in Early Stage Clonal Hypereosinophilic Syndrome
Imatinib is an excellent candidate for first line treatment of Loeffler's endocarditis, especially when the FIP1L1/PDGFA fusion gene is detected. Expand
The Spectrum of FIP1L1-PDGFRA-Associated Chronic Eosinophilic Leukemia
It is confirmed that an initial low-dose regimen of imatinib (100 mg/d) followed by a lower maintenance dose can be efficient for obtaining long-term CHR and CMR, and the data suggest thatImatinib can be stopped in some patients without molecular relapse. Expand
Heart Transplantation in a Patient with Endomyocardial Fibrosis Due to Hypereosinophilic Syndrome
The first case of a patient with endomyocardial fibrosis due to HES who underwent orthotopic heart transplantation at this institution is described. Expand
Cardiovascular manifestations of hypereosinophilic syndromes.
The diagnosis and management of the cardiovascular manifestations of HES are reviewed, including endomyocardial fibrosis, which is the most characteristic cardiovascular abnormality in HES. Expand
Endomyocardial Fibrosis: Still a Mystery after 60 Years
A systematic review of research on the epidemiology and etiology of endomyocardial fibrosis found that the volume of publications has declined since the 1980s and no account of the etiology has yet fully explained its unique geographical distribution. Expand
The spectrum of FIP1L1PDGFRA-associated chronic eosinophilic leukemia: new insights based on a survey of 44 cases.Medicine (Baltimore). 2013;Epub ahead of print
  • 2013