Successful Eradication of a Monoclonal Strain of Klebsiella pneumoniae during a K. pneumoniae Carbapenemase-Producing K. pneumoniae Outbreak in a Surgical Intensive Care Unit in Miami, Florida

@article{MunozPrice2010SuccessfulEO,
  title={Successful Eradication of a Monoclonal Strain of Klebsiella pneumoniae during a K. pneumoniae Carbapenemase-Producing K. pneumoniae Outbreak in a Surgical Intensive Care Unit in Miami, Florida},
  author={L. Silvia Munoz-Price and Carolina De La Cuesta and Stephen Adams and Mary Wyckoff and Timothy Cleary and Sandra P. McCurdy and Michael D. Huband and Margaret M Lemmon and Mary Kay Lescoe and Fadia B Dibhajj and Mary K. Hayden and Karen Lolans and John P Quinn},
  journal={Infection Control \&\#x0026; Hospital Epidemiology},
  year={2010},
  volume={31},
  pages={1074 - 1077}
}
We describe the investigation and control of a Klebsiella pneumoniae carbapenemase-producing K. pneumoniae outbreak in a 20-bed surgical intensive care unit during the period from January 1, 2009 through January 1, 2010. Nine patients were either colonized or infected with a monoclonal strain of K. pneumoniae. The implementation of a bundle of interventions on July 2009 successfully controlled the further horizontal spread of this organism.Ā 

Topics from this paper

Critical issues for Klebsiella pneumoniae KPC-carbapenemase producing K. pneumoniae infections: a critical agenda.
TLDR
Clinical data on KPC-Kp is reviewed at a time when a pro-active strategy is no longer useful, focusing on epidemiology, patient risk profile, infection control, digestive tract colonization and treatment issues such as the role of carbapenems orcarbapenem sparing strategies, colistin and resistance, dual carbapENem administration and the roleof tigecycline.
Outbreak of Klebsiella pneumoniae Carbapenemase–Producing Citrobacter freundii at a Tertiary Acute Care Facility in Miami, Florida
TLDR
The findings suggest that carbapenemase-producing C. freundii may be underdetected even when active surveillance is in place and has a potential to cause hospital outbreak.
Carbapenem-resistant Enterobacteriaceae: A menace to our most vulnerable patients
TLDR
The mechanisms of carbapenem resistance, the dissemination and clinical impact of these resistant organisms, and challenges to their detection, treatment, and control are reviewed.
Management of KPC-producing Klebsiella pneumoniae infections.
  • M. Bassetti, D. Giacobbe, +12 authors G. Poulakou
  • Medicine
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2018
Nosocomial Outbreak of VIM-1-Producing Klebsiella pneumoniae Isolates of Multilocus Sequence Type 15: Molecular Basis, Clinical Risk Factors, and Outcome
TLDR
A high rate of associated mortality and great difficulty in controlling the spread of this clone, without permanent behavioral changes in the personnel, were observed.
The Emergence of Carbapenemase-Producing Enterobacteriaceae
TLDR
Nosocomial Klebsiella isolates have exhibited increasing levels of commensal bacteria in the human bowel, which are common etiologies of both community and hospital-acquired infections.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 16 REFERENCES
Emergence of KPC-2 and KPC-3 in Carbapenem-Resistant Klebsiella pneumoniae Strains in an Israeli Hospital
TLDR
A sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006 is noticed, indicating rapid dissemination of KPC outside the United States.
Successful Control of an Outbreak of Klebsiella pneumoniae Carbapenemase—Producing K. pneumoniae at a Long-Term Acute Care Hospital
TLDR
A bundled intervention was successful in preventing horizontal spread of KPC-producing gram-negative rods in a long-term acute care hospital, despite ongoing admission of patients colonized with KPC producers.
Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium.
TLDR
Carapenem-resistant K pneumoniae isolates are rapidly emerging in New York City and automated systems used for susceptibility testing may not accurately identify all these isolates, which will severely hamper control efforts.
The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria.
Success of an Infection Control Program to Reduce the Spread of Carbapenem-Resistant Klebsiella pneumoniae
TLDR
The comprehensive intervention that combined intensified infection control measures with routine rectal surveillance cultures was helpful in reducing the incidence of carbapenem-resistant K. pneumoniae in an intensive care unit where strains producing the carbAPenemase KPC were endemic.
Klebsiella pneumoniae Carbapenemase–Producing Organisms: An Ounce of Prevention Really Is Worth a Pound of Cure
TLDR
It now appears that carbapenem-resistant Klebsiella strains are poised to take center stage as the next major challenge in antimicrobial resistance in health care.
Outcomes of Carbapenem-Resistant Klebsiella pneumoniae Infection and the Impact of Antimicrobial and Adjunctive Therapies
TLDR
The mortality rate associated with carbapenem-resistant K. pneumoniae infection and the limited antimicrobial options for treatment of carbapnem- resistant K.neume infection highlight the need for improved detection and development of novel agents with reliable clinical efficacy against this type of infection.
Direct Ertapenem Disk Screening Method for Identification of KPC-Producing Klebsiella pneumoniae and Escherichia coli in Surveillance Swab Specimens
TLDR
Direct ertapenem disk testing is simpler, more sensitive, and more specific than selective broth enrichment with imipenem for detection of KPC-producing K. pneumoniae and E. coli in surveillance specimens.
Risk Factors and Clinical Impact of Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae
TLDR
Limiting use of certain antimicrobials, specifically fluoroquinolones and cephalosporins, use may be effective strategies for prevention and infection control.
Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities.
Infection with carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing Enterobacteriaceae is emerging as an important challenge in health-care settings. Currently,…
...
1
2
...