Successful Control of Disseminated Scedosporium prolificans Infection with a Combination of Voriconazole and Terbinafine

@article{Howden2003SuccessfulCO,
  title={Successful Control of Disseminated Scedosporium prolificans Infection with a Combination of Voriconazole and Terbinafine},
  author={Benjamin P. Howden and Monica A. Slavin and Anthony P. Schwarer and Anne M. Mijch},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
  year={2003},
  volume={22},
  pages={111-113}
}
  • B. Howden, M. Slavin, +1 author A. Mijch
  • Published 14 February 2003
  • Medicine
  • European Journal of Clinical Microbiology and Infectious Diseases
Disseminated Scedosporium prolificans infections are almost uniformly fatal because of their resistance to antifungal agents. Recently, synergy between triazoles and terbinafine has been demonstrated against Scedosporium prolificans in vitro. Reported here is a patient who developed disseminated Scedosporium prolificans infection following bone marrow transplantation and who was successfully treated with a combination of voriconazole and terbinafine in addition to aggressive surgical… 
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Two cases of the successful treatment of S. apiospermum CNS infections with the combination of voriconazole and terbinafine are presented.
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References

SHOWING 1-10 OF 13 REFERENCES
Disseminated infection and colonization by Scedosporium prolificans: a review of 18 cases, 1990-1999.
TLDR
Scedosporium prolificans infection was analyzed in 18 patients from whom the fungus was isolated during the period 1990-1999, and 4 patients with leukemia died, 1 patient with breast cancer who underwent autologous bone marrow transplantation survived, and1 patient with advanced acquired immunodeficiency syndrome died, although the fungal infection did not seem to affect his clinical symptoms.
Disseminated infection by Scedosporium Prolificans: an emerging fatality among haematology patients. Case report and review
TLDR
A case of proven disseminated infection by Scedosporium prolificans in a profoundly neutropenic patient and reversal of the underlying deficient immune status appears of great importance is described.
In Vitro Interaction of Terbinafine with Itraconazole against Clinical Isolates of Scedosporium prolificans
ABSTRACT In order to develop new approaches for the chemotherapy of invasive infections caused by Scedosporium prolificans, the in vitro interaction between itraconazole and terbinafine against 20
Airborne outbreak of nosocomial Scedosporium prolificans infection
TLDR
It is concluded that fatal multidrug-resistant S prolificans epidemics can be aerially transmitted and can be prevented with implementation of appropriate infection-control measures.
Disseminated phaeohyphomycosis: review of an emerging mycosis.
TLDR
Disseminated phaeohyphomycosis is an uncommon infection caused by dematiaceous fungi, although the number of case reports has been increasing in recent years.
Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans and Scedosporium apiospermum.
TLDR
Voriconazole was much more active than fluconazole and flucytosine, moreactive than amphotericin B, itraconazole, ketoconazoles and ketoconzole and was as active as miconazoles against S. apiospermum isolates.
Synergistic interaction of terbinafine with triazoles or amphotericin B against Aspergillus species.
TLDR
The results suggest potential clinical application of terbinafine in aspergillosis, either alone or in combination with amphotericin or triazoles, or with itraconazole or voriconazole.
In Vitro Activities of New and Conventional Antifungal Agents against Clinical Scedosporium Isolates
TLDR
Low growth-inhibitory antifungal activities were found in vitro for most of the drugs tested against S. prolificans isolates, with the MICs at which 90% of isolates are inhibited (MIC90s) being >8 μg/ml; the MIC90s of voriconazole and UR-9825, however, were 4 μg/ ml.
In Vitro Fungicidal Activities of Voriconazole, Itraconazole, and Amphotericin B against Opportunistic Moniliaceous and Dematiaceous Fungi
TLDR
The role of the MFC as a predictor of clinical outcome needs to be established in clinical trials by following standardized testing conditions for determination of these in vitro values.
National Committee for Clinical Laboratory Standards.
Many members of the Academy of Pediatrics seem to be generally unaware of the fact that your Academy has participated for ten years in a very interesting and valuable organization, the National
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